A very good friend sent me a landmark study surrounding Ketamine a little while ago. In drug research, big effects and powerful findings are usually accompanied by tiny sample sizes and weird statistics magic to rig the findings. So when I read the meta-analysis and systematic review published in The American Journal of Psychiatry, I was heartened. This is serious science and serious stats, with 167 patients evaluated across multiple studies. Also, the reporting scales (MADRS, HAM-D, QIDS-SR & the BDI) are well understood, robust and respected in the field. All of this adds up to this results abstract being very, VERY important:
That’s a dense couple of sentences, so let me explain why it’s so earth shattering. Suicidal thoughts, (known as suicidal ideation in clinical psychology) and depressed feelings are very difficult to get rid of, especially for depressed people. Treatment-resistant depression is a term associated with someone who has attempted multiple types of treatment for their Axis I disorder, but it hasn’t gotten better. After trying multiple types of interventions with no success, people slide quickly into hopelessness and thoughts of self harm. Up until now, depression treatments like SSRI drugs and Cognitive Behavioral therapy take time to work, sometimes more than a month. If you’re not in a good place right now, these things can’t help you. Ketamine infusions help immediately, and the change is apparent both to the patient and to the interviewing physician afterwards. This bit is huge, as most drug research relies heavily on self-report, which leads to bias and distorted findings. But, people are already talking to the press swearing by it, and it’s getting quite a lot of press, so here’s what they’re talking about.
While the Best Coast has just about legalized the growth & sale of cannabis from the Mexican to Canadian borders, us poor unfortunate souls stuck in New England, the Mid-Atlantic, and what’s traditionally thought of as the Deep South, remain mired in drug reform purgatory. In New York state, medical cannabis laws allow for purchase of concentrates, edibles and, non-plant matter containing products that have THC/CBD, but dispensaries are few & far between, and there is a steep fee to obtain an MMJ license. In Massachusetts, cannabis became legal a full year before dispensaries are allowed to open, providing legal cover to people who can already access the stuff, while propagating the same patterns of arrest and harassment of gray/black market channels as before the law was passed. We’ve seen similar patterns of arrest for dealers who don’t play by the “tax stamp” rules in Colorado, but Washington DC takes the cake when it comes to cannabis market dysfunction.
In Washington DC, cannabis was legalized, but a congressional committee gets to review all laws the District of Columbia passes. Some asshole named Andy Harris, an anesthesiologist member of the “Freedom Caucus” who opposes the cannabis legalization, got a rider passed that prohibited DC from spending cash on figuring out how to tax or regulate pot. So, it remains legal to possess, but illegal to buy or sell. While this is one of the dumbest things you’ll hear all month, that hasn’t stopped DC. Businesses all over the city have started selling mugs, t-shirts, calendars, and tons of other swag with “a little something.” With DC police in no hurry to stamp out anything but the most in your face abuse of this system, we’re starting to see what happens when something that starts as Mutual Aid or gifting, turns into a market economy.
Enough people sent me the NY Times article about Fentanyl overtaking Heroin that I had to say something about it. If you’ve not seen it and the plurality of think pieces surrounding it, the only piece you need to read on it is by the person who runs The Dose Makes The Poison, Kevin Shanks. He’s been one of my go to sources on novel psychoactive substances for years now, and he, along with a handful of others have been yelling as loud as they possibly can. The point he raised almost a month ago is one I’ve not seen a single mainstream medical journal begin to grapple with in any kind of meaningful way.
As I’ve said for a while now, this ain’t your father’s heroin. At what point do we stop calling it heroin and refer to the standard “heroin” product on the street as fentanyl? ~Kevin Shanks (9/2/17)
While drug overdose deaths are up 22% from 2015 alone, fentanyl deaths doubled. That’s not including the fact that cases are severely under counted, given the volume of fentanyl analogs in circulation right now. I previously reported on the report coming out of Ohio with 24 analogs & active metabolites being identified. That, combined with the increased cost in testing for analog substances, we’ve arrived at a place where medical staff have no idea how many chemicals they’re not testing for. How many rural communities are testing for acrylfentanyl or butyrylfentanyl? How many rural communities are seeing analogs that we don’t even know about yet? Communities along the migratory arc that fentanyl takes from China into Western Canada or Mexico into border communities, that see these substances first, are they still getting the same analogs, or is there already something new? At this point, it’s likely the unknown unknowns are already on the ground and slowly being consumed for the first time.